Misoprostol and its various usages

Medical abortion necessarily needs two medications for successful termination. Even though their basic usage is for causing medically induced miscarriage, these pills are also used for different purposes. When you buy abortion pill, the secondary drug is called Misoprostol. It is a synthetic prostaglandin E analogue that is not only used for its intended purpose but also for off-label usage of indication in gynecology and obstetrics, inducing labor, treating stomach ulcers, ripening of cervix and medical management of miscarriage and treating hemorrhage after childbirth.  Additionally it is also listed as an ‘essential’ medicine for women’s health by World Health Organization.

History                             

The U.S FDA approved medication for pregnancy termination in 2000 with 600 mg and 400 mg of Mifepristone (Mifeprex) and Misoprostol (Cytotec) respectively. Before the recent amendment, the FDA required prescription of three pills of Mifeprex and two tablets of Misoprostol. Additionally, pregnancy cancellation medicines were only used up to 49 days of gestation. After the recent update on labeling, FDA now requires 800 mcg dosage of Misoprostol, i.e. four tablets of 200mcg dosage. This drug can be used orally (under the tongue), buccally (in the cheek pouches) and inserted vaginally. Generally, used orally before FDA update, now the drug is mostly administered buccally.

Success rate of its usage is approximately reported within 95%-98% indicating that it is safe. Candidates for using this drug must adhere to its strict rules of regimen and have access to transportation and communication to medical care. They have to buy Misoprostol, knowing its reactions, dosage, pre-cautions, contraindications and side-effects.

Its side effects

Its usual effects include bleeding and cramps. As it causes the conception tissues to be ejected through vaginal discharge, heavy bleeding and womb contractions are expected. Other side effects involve vomiting, nausea, diarrhea and weakness etc.

It is generally advised to whoever that decides to buy Misoprostol online, to check if the web source is genuine to prevent any ill-effects.

Cervical ripening usage

This uterine contraction inducing medication is also well known for its usage in cervical ripening.  As abortion in first trimester is less complicated, the risk factors concerning its usage are less than 1%. Risk factors include cases like cervical laceration, provider inexperience, perforation of uterus, patient aged less than 18 years of age and late gestation period.  Nevertheless, if the patient with above risks or otherwise has bought Misoprostol online for cervical ripening, it is generally advised that she must do so with the help of a medical practitioner.

Otherwise, optimal dosage required for first-trimester abortion is 400 mcg. There is data available evaluating its usage and effect routes of administration through orally and vaginally. The drug needs to be administered generally 8 to 12 hours orally and 3-4 hours early if inserted vaginally. It is reported that vaginal insertion shows fewer side effects than oral, although there are fewer chances of leftover pill residue when taken orally.

Treating hemorrhage after childbirth

As it contains uterotonic properties, this prostaglandin tablet is also used for preventing and treating post partum hemorrhage. Even though there is insufficient data supporting this, some health care providers use Misoprostol as a primary preventive measure for postpartum hemorrhage when other agents such as oxytocin and methylergotomine are not available or not effective.